Butyrfentanyl

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butyrylfentanyl is a potent short-acting synthetic opioid analgesic drug. It is an analog of fentanyl with around one quarter of its potency. Butyrfentanyl has no current legitimate clinical applications; however, it is being sold as designer drug.

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Buy Butyrfentanyl Online
Butyrylfentanyl is a potent short-acting synthetic opioid analgesic drug. It is an analog of fentanyl with around one quarter of its potency. Butyrfentanyl has no current legitimate clinical applications; however, it is being sold as designer drug.

Butyrfentanyl or butyrylfentanyl is a potent short-acting synthetic opioid analgelsic.It is an analogue of fentanyl with around one quarter of its potency. One of the first mentions of this drug can be found in document written by The College on Problem of Drug Dependence, where it is mentioned as N-butyramide fentanyl analog. This document also states that the article describing its clinical effects (analgesic studies, μ-, δ-, κ-opioid receptor binding, and in vitro measures of drug efficacy, antinociceptive, and narcotic properties) was published in 1987. It is an agonist for the μ-opioid receptors.

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching,nausea and potentially serious respiratory depression which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

Butyrfentanyl binds to the opioid receptor. During the studies of in vitro inhibition of specific [3H] fentanyl binding to the opioid receptor, the order of analogues was: (±)-cis-3-methylfentanyl > fentanyl = alpha-methylfentanyl > butyrylfentanyl > benzylfentanyl. The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined, revealed order: fentanyl = butyrylfentanyl > (±)-cis–3-methylfentanyl > benzylfentanyl > alpha-methylfentanyl. High cross-reactivity may be the effect of the shape of the molecule – the shape of butyrfentanyl is closest to the original fentanyl molecule, which makes it easy to bind by fentanyl antibodies.

The opioid receptor affinity of fentanyl and its analogs was determined from their inhibitory potency in a binding assay with [3H] fentanyl as the radioligand. The Ki value for butyrfentanyl was Ki=32 ± 4.1 nM. Comparing to fentanyl’s Ki (Ki=1.06 ± 0.15 nM), butyrfentanyl’s ability to displace [3H] fentanyl is low and it requires high concentrations of the drug.

 

Butyrfentanyl (butyryl fentanyl ) is an opioid analgesic drug that is an analog of fentanyl. Butyrfentanyl is an opioid medication. An opioid is sometimes called a narcotic. Fentanyl is used as part of anesthesia to help prevent pain after surgery or other medical procedure. Fentanyl may also be used for purposes not listed in this medication guide. Buy butyrfentanyl online. Buy butyrfentanyl for sale online. Pure butyrfentanyl powder. Buy butyrfentanyl usa. Buy butyrfentanyl china. Butyyrl fentanyl suppliers. Butyrfentanyl vendors

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This product is intended for forensic and research applications.
This product has been manufactured and tested to meet ISO17025:2005 and Guide 34:2009 guidelines
This product is intended to be used as an analytical reference standard
Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing

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