Diclazepam Powder

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Diclazepam (also known as Chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepam, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered.

Description

Buy Diclazepam Powder Online
Diclazepam (also known as Chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepam, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered.It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960.

In animal models it has a potency of approximately ten times that of diazepam, of which it is a structural analog.

Diclazepam is not currently marketed as a medication, but rather sold online as a research chemical. Its potency has not been systematically tested in humans, but its closest relatives and two main metabolites are lormetazepam,with a potency value of x10-12 of delorazepam which is roughly x10 the potency of diazepam.

Users should note that the sudden discontinuation of benzodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to taper one’s dose by gradually lowering the amount taken each day over a prolonged period of time rather than stopping use abruptly, as this can lead to crippling, potentially life-threatening withdrawal symptoms.

Diclazepam is a drug of the benzodiazepine class. Benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven-membered ring with the two nitrogen constituents located at R1 and R4. At R1, diclazepam is substituted with methyl group. Further, the benzodiazepine ring is bonded at R5 to a 2-chlorinated phenyl ring. R7 of the benzyl ring is also substituted with a chlorine group. Diclazepam also contains an oxygen group double bonded to R2 of its diazepine ring to form a ketone.
This oxygen substitution at R2 is shared with other benzodiazepine drugs with the suffix -azepam.
Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors.As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of diclazepam on the nervous system.

The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.

The effects(Muscle relaxation,Sedation,Motor control loss,Respiratory depression,Dizziness)

Sedation are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects
should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

 

Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.
 

Metabolism

Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N-demethylation to delorazepam, which can be detected in urine for 6 days following administration of the parent compound. Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N-demethylation.

 

Formal Name : 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
CAS Number : 2894-68-0
Molecular Formula : C16H12Cl2N2O
Formula Weight :  319.2
Purity :  ≥98%
Formulation : A neat solid
Solubility  (Learn about Variance in Solubility) 
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
Ethanol: 10 mg/ml

Abstract
Background: Recently the number of new psychoactive substances has significantly increased, becoming popular among experienced users of designer drugs. A significant group includes benzodiazepine derivatives, which have not been introduced as medications but are abused by people experimenting with new and classical psychoactive substances.
Case presentation: The aim of this paper was to present the case of a clonazolam ingestion by a person who was not habituated to benzodiazepines. The intake caused only prolonged coma, decreased muscle tone, and deep tendon reflexes without any other concomitant toxicity and cardio-respiratory failure.
Conclusions: Clonazolam concentrations in patient’s blood, measured three times were 0.077 mg/L, 0.015 mg/L, 0.009 mg/L after 4, 8 and 12 h, respectively. Clonazolam’s human toxicity has not been well established, so any case of poisoning should be closely monitored.
Keywords: Blood confirmation; Clonazolam; New designer benzodiazepine.

 

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